Well I did not have mine for the full 5 years but for over 3 1/2 years. I did not realize all the side effects I was experiencing from it until this past fall/winter. I had mine removed on April 17th this past spring. Some of my symptoms disappeared instantly, some took time (like the acne/bad face-took almost the past 2 months) and some went away but came back from time to time (the depression) but overall I would think you should start feeling a difference fairly quickly but expect some relapses. I did not gain a lot of weight, maybe 5-10 pounds and I still have not gotten all of this off (the bloating did go down about a week or to after) but I am not trying very hard at the momment to lose it, I am just trying to eat healthy.