I would agree that many (if not most) cases of Fibro and CFIDS have an infectious cause or at least are involved in a major way. Maybe not all cases are Lyme though. There are a few good tests to help rule in or rule out Lyme. Two of them are the biotoxin screening test (Bb creates a toxin) and the CD57 Stricker Panel Assay. More info ont these at: http://www.newchronicfatigue.info/testing