Clues to the surge in asthma and Crohn’s disease may be found in the universe of bacteria in our gut. by vairagi ..... Asthma Support Forum
Date: 9/5/2016 6:37:34 AM ( 5 years ago ago)
"----in the last 30 years, rates of asthma, type I diabetes, Crohn’s disease and other chronic illnesses have climbed. ---a world map showing asthma prevalence--- reveals that rates vary dramatically from country to country. --the United States, United Kingdom and Australia are (higher), --more than 10 percent of the population has asthma. Russia and China, on the other hand, (are lower, tho lack of diagnosis and reporting may be involved), --has asthma at 2.5 percent or less."
"For years, Marsha Wills-Karp, PhD, had used the same strains of laboratory mice to study the molecular mechanisms of asthma. And for years standard tests had shown that one commonly used strain, A/J mice, was susceptible to asthma, while another standard strain, C3H mice, was resistant to the disease.
That changed when Wills-Karp moved her lab from the Bloomberg School to the Cincinnati Children’s Hospital Medical Center 13 years ago. Suddenly, the A/J mice were less asthmatic, while the C3H mice were more susceptible to the disease.
“We were baffled,” says Wills-Karp.
"Other than geography, nothing had changed. The mice were the same genetic strains she had always used, ordered from the same company she had always patronized. Even the scientists handling the animals were the same—graduate students who had accompanied Wills-Karp to Cincinnati."
"The mystery (increased) in 2012 when Wills-Karp returned to the Bloomberg School to chair the Department of Environmental Health Sciences ----and the mice resumed their old patterns."
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