I actually had the most skin clearing I believe with iodine. I think the OP process helped skin tone, but it was after using Iodine internally and externally that I saw real change in terms of breakouts. I did see some improvement with OP alone and of course it is hard to attribute which results belong to which therapies (or combinations thereof) and I have never been great about just doing one thing for several months. But I think the cleansing effects of Iodine were ultimately the most helpful on a surface level, so to speak) in this regard.