Re: Q re supplements...please mpdela!

Hi again,

Under
http://www.genetests.org/query?dz=trimethylaminuria
, Gene Reviews, Trimethylaminuria, scroll down to Treatment of Manifestations, you’ll get the exact dosage and length of time of treatment to get rid of the extreme odor that is emitted the skin, breath, urine, saliva, and any other secretions. My son and I call this the short-term treatment because it’s prescribed for only for a certain amount of time.

SHORT-TERM TREATMENT FOR EXTREME ODOR
1. Low choline diet (According to the Institute of Medicine, National Academy of Sciences USA 1998, the adequate daily intake of choline is 550 mg for males and 425mg for females for adults) I don’t know if this also applies to people with TMAU. I guess it depends on how much FM03 you produce.

2. Activated charcoal: 700 mg twice daily for 10 days.

3. copper chlorophyllin: 60 mg three times a day after meals for 3 weeks

4. Vitamin B2 (riboflavin): 30-40 mg, three to five times a day with food to enhance the function of whatever FM03 your liver might still be producing

5. a short course of Antibiotics , NEOMYCIN, AMOXICILLIN, OR METRONIDAZOLE to modulate or reduce the activity of gut microflora, thus suppressing the production of trimethylamine (TMA)

6. Laxatives, such as lactulose, to decrease intestinal transit time may also reduce the amount of TMA produced in the gut

7. Replace the lactobacilli, also called the “friendly bacteria”, (L. acidophilus, and L. rhamnosus, B. lactis, Steptococcus thermophilus, and/or L. Bulgaricus) after cleaning out gut (recommended by The Trimethylaminuria Foundation in N.Y., based on other professional sources).

8. use acid soaps and body lotions with a pH factor of 5.5 to 6.5. Trimethylamine is a strong base (pH 9.8) that needs to be brought back down to a normal skin pH of 5.5 – 6.5.

LONG TERM, ONGOING TREATMENT THAT WORKS FOR MY SON (he came up with it himself based on trial and error) Now we just have to see how it works out on a long-term basis.
1. Low choline diet
2. Vitamin B2 (riboflavin): 100mg in the a.m. and 100 mg. in the p.m. daily
3. Activated charcoal: 500mg in the a.m. and another 500mg in the p.m. daily
4. cooper chlorophyllin: 200mg in a.m., and 100mg in p.m. daily
5. laxatives as needed, immediately followed by lactobacilli (acidophilus) replacement. NOTE: MUST BE KEPT REFRIGERATED OR THE BACTERIA DIES AT ROOM TEMPERATURE, and then you’re really not replacing the friendly bacteria in the gut.
6. Always use acid soaps (preferably with Sea Salt s) and body lotions with a 5.5-6.5 pH.
7. NO Antibiotics

In other words, I think the prescribed dosages recommended by the U.S. National Institute of Health intends to do a major “clean-up”, to get you odor free. Afterwards, I guess it’s up to you to find your own balancing act to maintain your odor-free condition based on the amount of FM03 your liver’s produces, if any. My son believes that the less you take with the desired effect, the better, and I agree.

ATA, where did you find info about the benefits of zinc specific for TMAU?

mpdela