DEFINITELY noticed a difference with saw p. right away; read my post further down about "3weeks and still clear". My wonderful dr told me about that transformation serum - it helped more than any other topical treatment. But it probably all depends on whether testo is your issue or not. If so, you'll probably notice an immediate improvement, as I did.
I had all those peels and micro-dermabrasion, etc, but they never affected my Acne at all. However, if they say that area is about stress, I almost agree, given that testosterone is rather stressful in itself!