Oh yes it will worsen insomnia very probably. Have read about people trying in in Chronic-Fatigue-Syndrome boards. Onw woman said she couldnt sleep in two weeks on LDN. I also have some degree of "CFS".I hate that diagnosis because in reality I have leaky gut, adrenal, thyroid and heavymetal/methylation issues. And everyone else with Chronic-Fatigue-Syndrome have these, either it started with an infection or metals or whatever.