from those I've spoken with the kids with Autism have equally a hard time holding activated Miracle-Mineral-Supplement in enema and still seems to work just fine. Maybe just get it in there the best you can for as long as possible and see what you see. Hint: 2 PM Solar time, (check the web to find your exact solar time) is the shunt for the Liver Cleansing time. Liver Cleansing is 2 AM...and a good time to get the Miracle-Mineral-Supplement into liver for flukes through the portal vein which is accessed in the sigmoid area so not a great deal of water is needed. try holding 10 oz.