Re: Fenbendazole vs piperazine for toxocara and toxascaris

FenBendazole to Piperazine is like a truck compared to a skimobile, very little relationship. No conclusions are warranted, and indeed none were made.

FenBen is a microtube suppressor, actually gums up the innards. Starves them.

Piperazine is a "reversible" smooth muscle paralyzer. Slows them down. Can keep them from feeding if taken for a long enough period of time. Since it has a fast half life of PPZ, it is normally required to be taken in small doses four times per day.

. This poorly constructed comparison says nothing.

Apples and oranges.

Different methods, actions, and uses. It is like the face off was constructed by someone in parasitology, unfamiliar with the mechanisms of use or dosing of either med. Poorly constructed at best in my "novice" opinion.

Neither med is put into its ideal configuration, the dosing configuration is done by an amateur.

Fisher wrote many papers, starting in the 1990's. Few of them look substantive.

No conclusions can be taken from such a poor misleading comparison of two drug classes.

None.

In my unqualified opinion - FenBen in subdermal "injection" dosing at lower levels is a more appropriate use, and delivery of the med, in dogs.

FenBen's high activity against a spectrum of dog roundworms, makes it one of the ideal choices.

Depending on the parasite species, I would be prepared for either bi-monthly, or an even smaller dose done weekly.

In a private paper I wrote last week, I proposed different dosing patterns for complicated infections.

One may take once a month dose at level X for infection A,

One may take once a week dose at level Y for infection B.

The goal is to minimize the accumulated dose over time to prevent tissue pathology. FenBen accumulates pathology over time.

I would expect better from many parasitology papers, but this is what you get from people who sit in a lab, and never practice what they preach.

Ever tried to get your personal cat or dog vet involved? Another experience in a huge informational vacuum. Ask them for a ELISA test, you will see haze in their eyes. The tests exist, but few vets even know about them.

I think some of the best papers are from horse and cattle vets. They seam to really know their stuff, the meds, and the tricks. Researchers just don't seam to get it like farmers and vets.